Asparaginase
Product name: Asparaginase
CAS Number: 9015-68-3
Introduction
| form | lyophilized powder |
| Quality Level | 200 |
| specific activity | 100-300 units/mg protein (biuret) |
| composition | Protein, ≥60% |
| storage temp. | 2-8°C |
General description
Asparaginase is a bacterial enzyme and also a chemotherapeutic drug.
Biochem/physiol Actions
Asparaginase (ASNase) products are usually obtained from Escherichia coli and Erwinia chrysanthemi. These enzymes can block the synthesis of protein in tumor cells. It shows high activity in the G1 phase of the cell cycle.It is capable of causing pancreatitis in leukemia patients.
Asparaginase is used in enzymatic assays and to convert asparagine to aspartic acid. Asparaginase is used to reduce the formation of acrylamide in starchy food products. It is also used as a chemotherapy agent for acute lymphoblastic leukemia. Product A3809 is from Escherichia coli and is provided as a lyophilized powder containing sodium chloride.
Asparaginase may cause cell death in leukemic cells by converting the necessary L-asparagine to aspartic acid and ammonia. Asparaginase is allosterically regulated and is crucial for proper cell functioning.
