Uricase
Product name: Uricase
CAS Number: 9002-12-4
Introduction
| recombinant | expressed in E. coli |
| form | lyophilized powder |
| specific activity | ≥2 units/mg solid |
| mol wt | 35 kDa by SDS-PAGE |
| storage temp. | −20°C |
| SMILES string | [P](=O)([O-])(OC3C(OC(C3O)N4C=CC(=O)NC4=O)CO)OCC1OC(C(C1O)O)N2C=CC(=O)NC2=O.[N+H4] |
| InChI | 1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3 |
| InChI key | VPXDHZMLJOJKOX-UHFFFAOYSA-N |
General description
Uricase deficient mice develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.
Uricase is a homo-tetrameric protein with its active sites at the head-to-tail monomer-dimer interface.
Physical form
Powder; contains citrate and sucrose
