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Poly(2-ethyl-2-oxazoline) (PEOX)
Product name: Poly(2-ethyl-2-oxazoline)
Synonym(s): PEOX, POx, PetOx, poly 2-ethyloxazoline, polyethyloxazoline
CAS Number: 25805-17-8
Introduction
form | solid |
mol wt | average Mw ~500,000 |
viscosity | 60-80 cSt, 10 % in H2O |
density | 1.14 g/mL at 25 °C (lit.) |
PDI | 3‑4 |
InChI | 1S/C5H9NO/c1-2-5-6-3-4-7-5/h2-4H2,1H3 |
InChI key | NYEZZYQZRQDLEH-UHFFFAOYSA-N |
Application
This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation.
Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Adhesion promoter in coatings. Heat sealing and remoistenable hot-melt adhesive
Features and Benefits
Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.
Physical form
N-propionyl substituted linear polyethylenimine